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Fusion gene ID: 43034 |
FusionGeneSummary for ZNF14_RGL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF14_RGL3 | Fusion gene ID: 43034 | Hgene | Tgene | Gene symbol | ZNF14 | RGL3 | Gene ID | 7561 | 57139 |
| Gene name | zinc finger protein 14 | ral guanine nucleotide dissociation stimulator like 3 | |
| Synonyms | GIOT-4|KOX6 | - | |
| Cytomap | 19p13.11 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 14gonadotropin inducible transcription repressor-4gonadotropin-inducible ovary transcription repressor 4zinc finger protein 14 (KOX 6)zinc finger protein KOX6 | ral guanine nucleotide dissociation stimulator-like 3RalGEF-like protein 3, mouse homologralGDS-like 3 | |
| Modification date | 20180403 | 20180329 | |
| UniProtAcc | P17017 | Q3MIN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000344099, | ENST00000380456, ENST00000568628, ENST00000393423, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 4=36 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF14 [Title/Abstract] AND RGL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A295-01A | ZNF14 | chr19 | 19843765 | - | RGL3 | chr19 | 11513382 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344099 | ENST00000380456 | ZNF14 | chr19 | 19843765 | - | RGL3 | chr19 | 11513382 | - |
| 5CDS-intron | ENST00000344099 | ENST00000568628 | ZNF14 | chr19 | 19843765 | - | RGL3 | chr19 | 11513382 | - |
| 5CDS-intron | ENST00000344099 | ENST00000393423 | ZNF14 | chr19 | 19843765 | - | RGL3 | chr19 | 11513382 | - |
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FusionProtFeatures for ZNF14_RGL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF14 | RGL3 |