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Fusion gene ID: 4299 |
FusionGeneSummary for BOLA2_HADHB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BOLA2_HADHB | Fusion gene ID: 4299 | Hgene | Tgene | Gene symbol | BOLA2 | HADHB | Gene ID | 654483 | 3032 |
| Gene name | bolA family member 2B | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | |
| Synonyms | BOLA2 | ECHB|MSTP029|MTPB|TP-BETA | |
| Cytomap | 16p11.2 | 2p23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | trifunctional enzyme subunit beta, mitochondrial2-enoyl-Coenzyme A (CoA) hydratase, beta subunit3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunitacetyl-CoA acyltransferasebeta-ketothiolasehydroxyacyl-CoA dehydr | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H3K6 | P55084 | |
| Ensembl transtripts involved in fusion gene | ENST00000330978, | ENST00000317799, ENST00000405867, ENST00000537713, ENST00000545822, ENST00000494615, | |
| Fusion gene scores | * DoF score | 24 X 31 X 3=2232 | 6 X 5 X 5=150 |
| # samples | 31 | 5 | |
| ** MAII score | log2(31/2232*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BOLA2 [Title/Abstract] AND HADHB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Hgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA426922 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000330978 | ENST00000317799 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
| intron-3CDS | ENST00000330978 | ENST00000405867 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
| intron-3CDS | ENST00000330978 | ENST00000537713 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
| intron-3CDS | ENST00000330978 | ENST00000545822 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
| intron-3UTR | ENST00000330978 | ENST00000494615 | BOLA2 | chr16 | 29830861 | - | HADHB | chr2 | 26486245 | + |
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FusionProtFeatures for BOLA2_HADHB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BOLA2 | HADHB |