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Fusion gene ID: 42974 |
FusionGeneSummary for ZMYND8_CEP250 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZMYND8_CEP250 | Fusion gene ID: 42974 | Hgene | Tgene | Gene symbol | ZMYND8 | CEP250 | Gene ID | 23613 | 11190 |
| Gene name | zinc finger MYND-type containing 8 | centrosomal protein 250 | |
| Synonyms | PRKCBP1|PRO2893|RACK7 | C-NAP1|CEP2|CNAP1 | |
| Cytomap | 20q13.12 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8 | centrosome-associated protein CEP250250 kDa centrosomal proteincentrosomal Nek2-associated protein 1 | |
| Modification date | 20180526 | 20180519 | |
| UniProtAcc | Q9ULU4 | Q9BV73 | |
| Ensembl transtripts involved in fusion gene | ENST00000311275, ENST00000360911, ENST00000458360, ENST00000262975, ENST00000471951, ENST00000352431, ENST00000396281, ENST00000446994, ENST00000536340, ENST00000355972, ENST00000540497, ENST00000461685, ENST00000372023, ENST00000468376, | ENST00000397527, ENST00000342580, ENST00000476146, ENST00000397524, | |
| Fusion gene scores | * DoF score | 12 X 9 X 6=648 | 6 X 6 X 4=144 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZMYND8 [Title/Abstract] AND CEP250 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CEP250 | GO:0000278 | mitotic cell cycle | 12140259 |
| Tgene | CEP250 | GO:0030997 | regulation of centriole-centriole cohesion | 9647649 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | XX000006 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000311275 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000311275 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000311275 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000311275 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000360911 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000360911 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000360911 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000360911 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000458360 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000458360 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000458360 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000458360 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| In-frame | ENST00000262975 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000262975 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000262975 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000262975 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000471951 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000471951 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000471951 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000471951 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000352431 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000352431 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000352431 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000352431 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000396281 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000396281 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000396281 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000396281 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| In-frame | ENST00000446994 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000446994 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000446994 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000446994 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000536340 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000536340 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000536340 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000536340 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| In-frame | ENST00000355972 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000355972 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000355972 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000355972 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000540497 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000540497 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000540497 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000540497 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000461685 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000461685 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000461685 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000461685 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| Frame-shift | ENST00000372023 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000372023 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000372023 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| 5CDS-intron | ENST00000372023 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| intron-3CDS | ENST00000468376 | ENST00000397527 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| intron-intron | ENST00000468376 | ENST00000342580 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| intron-intron | ENST00000468376 | ENST00000476146 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
| intron-intron | ENST00000468376 | ENST00000397524 | ZMYND8 | chr20 | 45852969 | - | CEP250 | chr20 | 34078460 | + |
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FusionProtFeatures for ZMYND8_CEP250 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZMYND8 | CEP250 |