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Fusion gene ID: 42973

FusionGeneSummary for ZMYND8_CELF5

Fusion gene summary

Fusion gene information	Fusion gene name: ZMYND8_CELF5
	Fusion gene ID: 42973
		Hgene	Tgene
	Gene symbol	ZMYND8	CELF5
	Gene ID	23613	60680
	Gene name	zinc finger MYND-type containing 8	CUGBP Elav-like family member 5
	Synonyms	PRKCBP1\|PRO2893\|RACK7	BRUNOL-5\|BRUNOL5\|CELF-5
	Cytomap	20q13.12	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8	CUGBP Elav-like family member 5CUG-BP and ETR-3 like factor 5RNA-binding protein BRUNOL-5bruno-like 5 RNA binding protein
	Modification date	20180526	20180523
	UniProtAcc	Q9ULU4	Q8N6W0
	Ensembl transtripts involved in fusion gene	ENST00000311275, ENST00000360911, ENST00000458360, ENST00000262975, ENST00000471951, ENST00000352431, ENST00000396281, ENST00000446994, ENST00000536340, ENST00000355972, ENST00000540497, ENST00000461685, ENST00000372023, ENST00000468376,	ENST00000292672, ENST00000541430, ENST00000588101,
Fusion gene scores	* DoF score	12 X 9 X 6=648	3 X 5 X 5=75
	# samples	13	8
	** MAII score	log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/75*10)=0.0931094043914815 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZMYND8 [Title/Abstract] AND CELF5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CELF5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	11158314

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-E2-A1LL-01A	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000311275	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000311275	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000311275	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000360911	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000360911	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000360911	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000458360	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000458360	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000458360	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000262975	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000262975	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000262975	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000471951	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000471951	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000471951	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000352431	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000352431	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000352431	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000396281	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000396281	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000396281	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000446994	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000446994	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000446994	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000536340	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000536340	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000536340	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000355972	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
Frame-shift	ENST00000355972	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000355972	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000540497	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000540497	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000540497	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000461685	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000461685	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000461685	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000372023	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
In-frame	ENST00000372023	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
5CDS-intron	ENST00000372023	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
intron-3CDS	ENST00000468376	ENST00000292672	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
intron-3CDS	ENST00000468376	ENST00000541430	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+
intron-intron	ENST00000468376	ENST00000588101	ZMYND8	chr20	45976600	-	CELF5	chr19	3250983	+

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FusionProtFeatures for ZMYND8_CELF5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZMYND8 Q9ULU4	CELF5 Q8N6W0

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Fusion gene ID: 42973

FusionGeneSummary for ZMYND8_CELF5

FusionProtFeatures for ZMYND8_CELF5