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Fusion gene ID: 4295 |
FusionGeneSummary for BOLA2_CPNE7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BOLA2_CPNE7 | Fusion gene ID: 4295 | Hgene | Tgene | Gene symbol | BOLA2 | CPNE7 | Gene ID | 654483 | 27132 |
| Gene name | bolA family member 2B | copine 7 | |
| Synonyms | BOLA2 | - | |
| Cytomap | 16p11.2 | 16q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | copine-7copine VII | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H3K6 | Q9UBL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000330978, | ENST00000268720, ENST00000319518, ENST00000566398, | |
| Fusion gene scores | * DoF score | 24 X 31 X 3=2232 | 2 X 2 X 2=8 |
| # samples | 31 | 2 | |
| ** MAII score | log2(31/2232*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BOLA2 [Title/Abstract] AND CPNE7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Hgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Tgene | CPNE7 | GO:0071277 | cellular response to calcium ion | 21087455 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA524880 | BOLA2 | chr16 | 29824648 | + | CPNE7 | chr16 | 89663405 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000330978 | ENST00000268720 | BOLA2 | chr16 | 29824648 | + | CPNE7 | chr16 | 89663405 | + |
| intron-3UTR | ENST00000330978 | ENST00000319518 | BOLA2 | chr16 | 29824648 | + | CPNE7 | chr16 | 89663405 | + |
| intron-intron | ENST00000330978 | ENST00000566398 | BOLA2 | chr16 | 29824648 | + | CPNE7 | chr16 | 89663405 | + |
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FusionProtFeatures for BOLA2_CPNE7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BOLA2 | CPNE7 |