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Fusion gene ID: 42896 |
FusionGeneSummary for ZHX3_SMG9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZHX3_SMG9 | Fusion gene ID: 42896 | Hgene | Tgene | Gene symbol | ZHX3 | SMG9 | Gene ID | 23051 | 56006 |
| Gene name | zinc fingers and homeoboxes 3 | SMG9, nonsense mediated mRNA decay factor | |
| Synonyms | TIX1 | C19orf61|F17127_1|HBMS | |
| Cytomap | 20q12 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc fingers and homeoboxes protein 3triple homeobox 1triple homeobox protein 1zinc finger and homeodomain protein 3 | protein SMG9protein smg-9 homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H4I2 | Q9H0W8 | |
| Ensembl transtripts involved in fusion gene | ENST00000309060, ENST00000540170, ENST00000559234, ENST00000557816, ENST00000558993, ENST00000544979, ENST00000560361, ENST00000432768, ENST00000561291, | ENST00000270066, ENST00000601170, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZHX3 [Title/Abstract] AND SMG9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZHX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12659632 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-TS-A7P7-01A | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000309060 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000309060 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000540170 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000540170 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000559234 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000559234 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000557816 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000557816 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000558993 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000558993 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000544979 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000544979 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| 5UTR-3CDS | ENST00000560361 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| 5UTR-3CDS | ENST00000560361 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000432768 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| intron-3CDS | ENST00000432768 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| 5UTR-3CDS | ENST00000561291 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
| 5UTR-3CDS | ENST00000561291 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
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FusionProtFeatures for ZHX3_SMG9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZHX3 | SMG9 |