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Fusion gene ID: 42879 |
FusionGeneSummary for ZFYVE9_ECHDC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFYVE9_ECHDC2 | Fusion gene ID: 42879 | Hgene | Tgene | Gene symbol | ZFYVE9 | ECHDC2 | Gene ID | 9372 | 55268 |
| Gene name | zinc finger FYVE-type containing 9 | enoyl-CoA hydratase domain containing 2 | |
| Synonyms | MADHIP|NSP|PPP1R173|SARA|SMADIP | - | |
| Cytomap | 1p32.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger FYVE domain-containing protein 9MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchorMADH-interacting proteinnovel serine proteaseprotein phosphatase 1, regulatory subunit 173smad anchor for receptor | enoyl-CoA hydratase domain-containing protein 2, mitochondrialenoyl Coenzyme A hydratase domain containing 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95405 | Q86YB7 | |
| Ensembl transtripts involved in fusion gene | ENST00000357206, ENST00000287727, ENST00000371591, ENST00000469134, | ENST00000371522, ENST00000358358, ENST00000536120, ENST00000541281, ENST00000480312, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFYVE9 [Title/Abstract] AND ECHDC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A23U-01A | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357206 | ENST00000371522 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000357206 | ENST00000358358 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000357206 | ENST00000536120 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000357206 | ENST00000541281 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000357206 | ENST00000480312 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000287727 | ENST00000371522 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000287727 | ENST00000358358 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000287727 | ENST00000536120 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000287727 | ENST00000541281 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000287727 | ENST00000480312 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000371591 | ENST00000371522 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000371591 | ENST00000358358 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| In-frame | ENST00000371591 | ENST00000536120 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000371591 | ENST00000541281 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 5CDS-intron | ENST00000371591 | ENST00000480312 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 3UTR-3CDS | ENST00000469134 | ENST00000371522 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 3UTR-3CDS | ENST00000469134 | ENST00000358358 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 3UTR-3CDS | ENST00000469134 | ENST00000536120 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 3UTR-intron | ENST00000469134 | ENST00000541281 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
| 3UTR-intron | ENST00000469134 | ENST00000480312 | ZFYVE9 | chr1 | 52769597 | + | ECHDC2 | chr1 | 53364896 | - |
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FusionProtFeatures for ZFYVE9_ECHDC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFYVE9 | ECHDC2 |