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Fusion gene ID: 42859 |
FusionGeneSummary for ZFYVE16_BDP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFYVE16_BDP1 | Fusion gene ID: 42859 | Hgene | Tgene | Gene symbol | ZFYVE16 | BDP1 | Gene ID | 9765 | 55814 |
| Gene name | zinc finger FYVE-type containing 16 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | |
| Synonyms | PPP1R69 | HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | |
| Cytomap | 5q14.1 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger FYVE domain-containing protein 16endosome-associated FYVE-domain proteinprotein phosphatase 1, regulatory subunit 69zinc finger, FYVE domain containing 16 | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z3T8 | A6H8Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000338008, ENST00000510158, ENST00000505560, ENST00000512442, | ENST00000358731, ENST00000380675, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 4 X 3=36 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFYVE16 [Title/Abstract] AND BDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4449-01A | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000338008 | ENST00000358731 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| In-frame | ENST00000338008 | ENST00000380675 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| Frame-shift | ENST00000510158 | ENST00000358731 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| In-frame | ENST00000510158 | ENST00000380675 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| Frame-shift | ENST00000505560 | ENST00000358731 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| In-frame | ENST00000505560 | ENST00000380675 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| intron-3CDS | ENST00000512442 | ENST00000358731 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
| intron-3CDS | ENST00000512442 | ENST00000380675 | ZFYVE16 | chr5 | 79735851 | + | BDP1 | chr5 | 70848943 | + |
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FusionProtFeatures for ZFYVE16_BDP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFYVE16 | BDP1 |