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Fusion gene ID: 42789 |
FusionGeneSummary for ZFHX3_ALS2CR11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFHX3_ALS2CR11 | Fusion gene ID: 42789 | Hgene | Tgene | Gene symbol | ZFHX3 | ALS2CR11 | Gene ID | 463 |
| Gene name | zinc finger homeobox 3 | ||
| Synonyms | ATBF1|ATBT|ZNF927 | ||
| Cytomap | 16q22.2-q22.3 | ||
| Type of gene | protein-coding | ||
| Description | zinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1ZFH-3alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3 | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q15911 | ||
| Ensembl transtripts involved in fusion gene | ENST00000268489, ENST00000397992, ENST00000558842, | ENST00000286195, ENST00000439802, ENST00000439140, ENST00000482942, ENST00000450242, | |
| Fusion gene scores | * DoF score | 12 X 9 X 7=756 | 2 X 2 X 2=8 |
| # samples | 15 | 2 | |
| ** MAII score | log2(15/756*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZFHX3 [Title/Abstract] AND ALS2CR11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZFHX3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11314020 |
| Hgene | ZFHX3 | GO:0045893 | positive regulation of transcription, DNA-templated | 20599712 |
| Hgene | ZFHX3 | GO:0071559 | response to transforming growth factor beta | 20599712 |