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Fusion gene ID: 42763

FusionGeneSummary for ZFAND6_DLEU1

Fusion gene summary

Fusion gene information	Fusion gene name: ZFAND6_DLEU1
	Fusion gene ID: 42763
		Hgene	Tgene
	Gene symbol	ZFAND6	DLEU1
	Gene ID	54469	10301
	Gene name	zinc finger AN1-type containing 6	deleted in lymphocytic leukemia 1
	Synonyms	AWP1\|ZA20D3\|ZFAND5B	BCMS\|BCMS1\|DLB1\|DLEU2\|LEU1\|LEU2\|LINC00021\|NCRNA00021\|XTP6
	Cytomap	15q25.1	13q14.2-q14.3
	Type of gene	protein-coding	ncRNA
	Description	AN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6	B-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21
	Modification date	20180522	20180519
	UniProtAcc	Q6FIF0	O43261
	Ensembl transtripts involved in fusion gene	ENST00000261749, ENST00000561060, ENST00000559157, ENST00000558494, ENST00000559835, ENST00000559775, ENST00000558688, ENST00000558087,	ENST00000490577, ENST00000378180,
Fusion gene scores	* DoF score	5 X 3 X 2=30	6 X 5 X 5=150
	# samples	4	6
	** MAII score	log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZFAND6 [Title/Abstract] AND DLEU1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SKCM	TCGA-D3-A2J6-06A	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000261749	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000261749	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000561060	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000561060	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000559157	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000559157	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000558494	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
5UTR-intron	ENST00000558494	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000559835	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000559835	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000559775	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000559775	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000558688	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000558688	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000558087	ENST00000490577	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+
intron-intron	ENST00000558087	ENST00000378180	ZFAND6	chr15	80352151	+	DLEU1	chr13	50657278	+

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FusionProtFeatures for ZFAND6_DLEU1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZFAND6 Q6FIF0	DLEU1 O43261

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Fusion gene ID: 42763

FusionGeneSummary for ZFAND6_DLEU1

FusionProtFeatures for ZFAND6_DLEU1