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Fusion gene ID: 42734 |
FusionGeneSummary for ZEB2_PAFAH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZEB2_PAFAH2 | Fusion gene ID: 42734 | Hgene | Tgene | Gene symbol | ZEB2 | PAFAH2 | Gene ID | 9839 | 5051 |
| Gene name | zinc finger E-box binding homeobox 2 | platelet activating factor acetylhydrolase 2 | |
| Synonyms | HSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B | HSD-PLA2 | |
| Cytomap | 2q22.3 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1b | platelet-activating factor acetylhydrolase 2, cytoplasmicSD-PLA2platelet-activating factor acetylhydrolase 2, 40kDaserine-dependent phospholipase A2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O60315 | Q99487 | |
| Ensembl transtripts involved in fusion gene | ENST00000558170, ENST00000409487, ENST00000303660, ENST00000539609, ENST00000493689, ENST00000470879, ENST00000465070, ENST00000462355, | ENST00000374282, ENST00000374284, ENST00000493892, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/50*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ZEB2 [Title/Abstract] AND PAFAH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZEB2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12837246|20516212 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK129536 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000558170 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000558170 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000558170 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000409487 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000409487 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000409487 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000303660 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000303660 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000303660 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000539609 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000539609 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000539609 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000493689 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000493689 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000493689 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000470879 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000470879 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000470879 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000465070 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000465070 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000465070 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000462355 | ENST00000374282 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-3UTR | ENST00000462355 | ENST00000374284 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
| intron-intron | ENST00000462355 | ENST00000493892 | ZEB2 | chr2 | 145267236 | - | PAFAH2 | chr1 | 26287504 | - |
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FusionProtFeatures for ZEB2_PAFAH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZEB2 | PAFAH2 |