|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 42702 |
FusionGeneSummary for ZDHHC2_FGD6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZDHHC2_FGD6 | Fusion gene ID: 42702 | Hgene | Tgene | Gene symbol | ZDHHC2 | FGD6 | Gene ID | 51201 | 55785 |
| Gene name | zinc finger DHHC-type containing 2 | FYVE, RhoGEF and PH domain containing 6 | |
| Synonyms | DHHC2|ZNF372 | ZFYVE24 | |
| Cytomap | 8p22 | 12q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | palmitoyltransferase ZDHHC2DHHC-2reamrecreduced expression associated with metastasis proteinreduced expression in cancer proteintestis tissue sperm-binding protein Li 56ezinc finger DHHC domain-containing protein 2zinc finger protein 372zinc fin | FYVE, RhoGEF and PH domain-containing protein 6zinc finger FYVE domain-containing protein 24 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UIJ5 | Q6ZV73 | |
| Ensembl transtripts involved in fusion gene | ENST00000262096, | ENST00000343958, ENST00000546711, ENST00000549499, ENST00000550368, | |
| Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZDHHC2 [Title/Abstract] AND FGD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZDHHC2 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB36-01A | ZDHHC2 | chr8 | 17014362 | + | FGD6 | chr12 | 95479684 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000262096 | ENST00000343958 | ZDHHC2 | chr8 | 17014362 | + | FGD6 | chr12 | 95479684 | - |
| Frame-shift | ENST00000262096 | ENST00000546711 | ZDHHC2 | chr8 | 17014362 | + | FGD6 | chr12 | 95479684 | - |
| 5CDS-intron | ENST00000262096 | ENST00000549499 | ZDHHC2 | chr8 | 17014362 | + | FGD6 | chr12 | 95479684 | - |
| 5CDS-intron | ENST00000262096 | ENST00000550368 | ZDHHC2 | chr8 | 17014362 | + | FGD6 | chr12 | 95479684 | - |
Top |
FusionProtFeatures for ZDHHC2_FGD6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZDHHC2 | FGD6 |