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Fusion gene ID: 42662 |
FusionGeneSummary for ZDHHC14_ARID1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZDHHC14_ARID1B | Fusion gene ID: 42662 | Hgene | Tgene | Gene symbol | ZDHHC14 | ARID1B | Gene ID | 79683 | 57492 |
| Gene name | zinc finger DHHC-type containing 14 | AT-rich interaction domain 1B | |
| Synonyms | NEW1CP | 6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250R | |
| Cytomap | 6q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger, DHHC domain containing 14 | AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | Q8IZN3 | Q8NFD5 | |
| Ensembl transtripts involved in fusion gene | ENST00000414563, ENST00000359775, ENST00000341375, | ENST00000350026, ENST00000346085, ENST00000367148, ENST00000275248, ENST00000478761, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 5 X 6 X 3=90 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZDHHC14 [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZDHHC14 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-K1-A42X-01A | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000414563 | ENST00000350026 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000414563 | ENST00000346085 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000414563 | ENST00000367148 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000414563 | ENST00000275248 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| 5CDS-intron | ENST00000414563 | ENST00000478761 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000359775 | ENST00000350026 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000359775 | ENST00000346085 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000359775 | ENST00000367148 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| Frame-shift | ENST00000359775 | ENST00000275248 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| 5CDS-intron | ENST00000359775 | ENST00000478761 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| intron-3CDS | ENST00000341375 | ENST00000350026 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| intron-3CDS | ENST00000341375 | ENST00000346085 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| intron-3CDS | ENST00000341375 | ENST00000367148 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| intron-3CDS | ENST00000341375 | ENST00000275248 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
| intron-intron | ENST00000341375 | ENST00000478761 | ZDHHC14 | chr6 | 157803298 | + | ARID1B | chr6 | 157431606 | + |
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FusionProtFeatures for ZDHHC14_ARID1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZDHHC14 | ARID1B |