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Fusion gene ID: 42627 |
FusionGeneSummary for ZCCHC17_FABP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZCCHC17_FABP3 | Fusion gene ID: 42627 | Hgene | Tgene | Gene symbol | ZCCHC17 | FABP3 | Gene ID | 51538 | 2170 |
| Gene name | zinc finger CCHC-type containing 17 | fatty acid binding protein 3 | |
| Synonyms | HSPC251|PS1D|pNO40 | FABP11|H-FABP|M-FABP|MDGI|O-FABP | |
| Cytomap | 1p35.2 | 1p35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17 | fatty acid-binding protein, heartfatty acid binding protein 11fatty acid binding protein 3, muscle and heartheart-type fatty acid-binding proteinmammary-derived growth inhibitormuscle fatty acid-binding protein | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q9NP64 | P05413 | |
| Ensembl transtripts involved in fusion gene | ENST00000344147, ENST00000479629, ENST00000373714, ENST00000546109, ENST00000422613, | ENST00000373713, ENST00000497275, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZCCHC17 [Title/Abstract] AND FABP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-0786-01B | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344147 | ENST00000373713 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 5CDS-5UTR | ENST00000344147 | ENST00000497275 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 3UTR-3CDS | ENST00000479629 | ENST00000373713 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 3UTR-5UTR | ENST00000479629 | ENST00000497275 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| In-frame | ENST00000373714 | ENST00000373713 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 5CDS-5UTR | ENST00000373714 | ENST00000497275 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| In-frame | ENST00000546109 | ENST00000373713 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 5CDS-5UTR | ENST00000546109 | ENST00000497275 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| In-frame | ENST00000422613 | ENST00000373713 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
| 5CDS-5UTR | ENST00000422613 | ENST00000497275 | ZCCHC17 | chr1 | 31792013 | + | FABP3 | chr1 | 31842404 | - |
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FusionProtFeatures for ZCCHC17_FABP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZCCHC17 | FABP3 |