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Fusion gene ID: 42605

FusionGeneSummary for ZC3H7B_SLC9A8

Fusion gene summary

Fusion gene information	Fusion gene name: ZC3H7B_SLC9A8
	Fusion gene ID: 42605
		Hgene	Tgene
	Gene symbol	ZC3H7B	SLC9A8
	Gene ID	23264	23315
	Gene name	zinc finger CCCH-type containing 7B	solute carrier family 9 member A8
	Synonyms	RoXaN	NHE-8\|NHE8
	Cytomap	22q13.2	20q13.13
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN	sodium/hydrogen exchanger 8Na(+)/H(+) exchanger 8solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9 (sodium/hydrogen exchanger), member 8solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
	Modification date	20180519	20180523
	UniProtAcc	Q9UGR2	Q9Y2E8
	Ensembl transtripts involved in fusion gene	ENST00000352645, ENST00000351589,	ENST00000417961, ENST00000361573, ENST00000541138, ENST00000539601, ENST00000490250,
Fusion gene scores	* DoF score	9 X 7 X 7=441	6 X 6 X 4=144
	# samples	11	8
	** MAII score	log2(11/441*10)=-2.00327513203286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZC3H7B [Title/Abstract] AND SLC9A8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	OV	TCGA-61-2111-01A	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000352645	ENST00000417961	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
Frame-shift	ENST00000352645	ENST00000361573	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
In-frame	ENST00000352645	ENST00000541138	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
Frame-shift	ENST00000352645	ENST00000539601	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
5CDS-3UTR	ENST00000352645	ENST00000490250	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
In-frame	ENST00000351589	ENST00000417961	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
Frame-shift	ENST00000351589	ENST00000361573	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
In-frame	ENST00000351589	ENST00000541138	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
Frame-shift	ENST00000351589	ENST00000539601	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+
5CDS-3UTR	ENST00000351589	ENST00000490250	ZC3H7B	chr22	41742212	+	SLC9A8	chr20	48504366	+

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FusionProtFeatures for ZC3H7B_SLC9A8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZC3H7B Q9UGR2	SLC9A8 Q9Y2E8

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Fusion gene ID: 42605

FusionGeneSummary for ZC3H7B_SLC9A8

FusionProtFeatures for ZC3H7B_SLC9A8