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Fusion gene ID: 42601 |
FusionGeneSummary for ZC3H7B_MICALL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3H7B_MICALL1 | Fusion gene ID: 42601 | Hgene | Tgene | Gene symbol | ZC3H7B | MICALL1 | Gene ID | 23264 | 85377 |
| Gene name | zinc finger CCCH-type containing 7B | MICAL like 1 | |
| Synonyms | RoXaN | MICAL-L1|MIRAB13 | |
| Cytomap | 22q13.2 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN | MICAL-like protein 1molecule interacting with Rab13 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9UGR2 | Q8N3F8 | |
| Ensembl transtripts involved in fusion gene | ENST00000352645, ENST00000351589, | ENST00000215957, ENST00000402631, | |
| Fusion gene scores | * DoF score | 9 X 7 X 7=441 | 6 X 5 X 6=180 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/441*10)=-2.00327513203286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZC3H7B [Title/Abstract] AND MICALL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MICALL1 | GO:0097320 | plasma membrane tubulation | 23596323 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-XV-AAZY-01A | ZC3H7B | chr22 | 41723368 | + | MICALL1 | chr22 | 38307959 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000352645 | ENST00000215957 | ZC3H7B | chr22 | 41723368 | + | MICALL1 | chr22 | 38307959 | + |
| 5CDS-intron | ENST00000352645 | ENST00000402631 | ZC3H7B | chr22 | 41723368 | + | MICALL1 | chr22 | 38307959 | + |
| Frame-shift | ENST00000351589 | ENST00000215957 | ZC3H7B | chr22 | 41723368 | + | MICALL1 | chr22 | 38307959 | + |
| 5CDS-intron | ENST00000351589 | ENST00000402631 | ZC3H7B | chr22 | 41723368 | + | MICALL1 | chr22 | 38307959 | + |
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FusionProtFeatures for ZC3H7B_MICALL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3H7B | MICALL1 |