|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 42573 |
FusionGeneSummary for ZC3H18_CHMP1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3H18_CHMP1A | Fusion gene ID: 42573 | Hgene | Tgene | Gene symbol | ZC3H18 | CHMP1A | Gene ID | 124245 | 5119 |
| Gene name | zinc finger CCCH-type containing 18 | charged multivesicular body protein 1A | |
| Synonyms | NHN1 | CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A | |
| Cytomap | 16q24.2 | 16q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 18conserved nuclear protein NHN1nuclear protein NHN1 | charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86VM9 | Q9HD42 | |
| Ensembl transtripts involved in fusion gene | ENST00000301011, ENST00000452588, | ENST00000397901, ENST00000253475, ENST00000535997, ENST00000550102, ENST00000547614, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 15 X 8 X 9=1080 |
| # samples | 7 | 20 | |
| ** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1080*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZC3H18 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHMP1A | GO:0007076 | mitotic chromosome condensation | 11559747 |
| Tgene | CHMP1A | GO:0016192 | vesicle-mediated transport | 11559748 |
| Tgene | CHMP1A | GO:0016458 | gene silencing | 11559747 |
| Tgene | CHMP1A | GO:0045892 | negative regulation of transcription, DNA-templated | 11559747 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0210-01A | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| TCGA | RV | GBM | TCGA-06-0210-02A | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000301011 | ENST00000397901 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000301011 | ENST00000253475 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000301011 | ENST00000535997 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000301011 | ENST00000550102 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-5UTR | ENST00000301011 | ENST00000547614 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000452588 | ENST00000397901 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000452588 | ENST00000253475 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000452588 | ENST00000535997 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-3CDS | ENST00000452588 | ENST00000550102 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
| 5UTR-5UTR | ENST00000452588 | ENST00000547614 | ZC3H18 | chr16 | 88636974 | + | CHMP1A | chr16 | 89713739 | - |
Top |
FusionProtFeatures for ZC3H18_CHMP1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3H18 | CHMP1A |