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Fusion gene ID: 42535 |
FusionGeneSummary for ZBTB7A_MLLT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB7A_MLLT1 | Fusion gene ID: 42535 | Hgene | Tgene | Gene symbol | ZBTB7A | MLLT1 | Gene ID | 51341 | 4298 |
| Gene name | zinc finger and BTB domain containing 7A | MLLT1, super elongation complex subunit | |
| Synonyms | FBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemon | ENL|LTG19|YEATS1 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor | protein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homol | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95365 | Q03111 | |
| Ensembl transtripts involved in fusion gene | ENST00000322357, ENST00000601588, | ENST00000252674, ENST00000585588, | |
| Fusion gene scores | * DoF score | 7 X 8 X 6=336 | 10 X 20 X 6=1200 |
| # samples | 8 | 25 | |
| ** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/1200*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZBTB7A [Title/Abstract] AND MLLT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A15P-01A | ZBTB7A | chr19 | 4055010 | - | MLLT1 | chr19 | 6270770 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000322357 | ENST00000252674 | ZBTB7A | chr19 | 4055010 | - | MLLT1 | chr19 | 6270770 | - |
| intron-intron | ENST00000322357 | ENST00000585588 | ZBTB7A | chr19 | 4055010 | - | MLLT1 | chr19 | 6270770 | - |
| intron-3CDS | ENST00000601588 | ENST00000252674 | ZBTB7A | chr19 | 4055010 | - | MLLT1 | chr19 | 6270770 | - |
| intron-intron | ENST00000601588 | ENST00000585588 | ZBTB7A | chr19 | 4055010 | - | MLLT1 | chr19 | 6270770 | - |
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FusionProtFeatures for ZBTB7A_MLLT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB7A | MLLT1 |