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Fusion gene ID: 42517 |
FusionGeneSummary for ZBTB48_ARHGEF39 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB48_ARHGEF39 | Fusion gene ID: 42517 | Hgene | Tgene | Gene symbol | ZBTB48 | ARHGEF39 | Gene ID | 3104 | 84904 |
| Gene name | zinc finger and BTB domain containing 48 | Rho guanine nucleotide exchange factor 39 | |
| Synonyms | HKR3|TZAP|ZNF855|pp9964 | C9orf100 | |
| Cytomap | 1p36.31 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | telomere zinc finger-associated proteinGLI-Kruppel family member HKR3krueppel-related zinc finger protein 3telomeric zinc finger-associated proteinzinc finger and BTB domain-containing protein 48zinc finger protein 855 | rho guanine nucleotide exchange factor 39Rho guanine nucleotide exchange factor (GEF) 39vav-like protein C9orf100 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P10074 | Q8N4T4 | |
| Ensembl transtripts involved in fusion gene | ENST00000377674, | ENST00000343259, ENST00000378387, ENST00000378395, ENST00000490970, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZBTB48 [Title/Abstract] AND ARHGEF39 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARHGEF39 | GO:0030335 | positive regulation of cell migration | 22327280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF915076 | ZBTB48 | chr1 | 6649165 | + | ARHGEF39 | chr9 | 35675565 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377674 | ENST00000343259 | ZBTB48 | chr1 | 6649165 | + | ARHGEF39 | chr9 | 35675565 | - |
| 5CDS-intron | ENST00000377674 | ENST00000378387 | ZBTB48 | chr1 | 6649165 | + | ARHGEF39 | chr9 | 35675565 | - |
| 5CDS-intron | ENST00000377674 | ENST00000378395 | ZBTB48 | chr1 | 6649165 | + | ARHGEF39 | chr9 | 35675565 | - |
| 5CDS-intron | ENST00000377674 | ENST00000490970 | ZBTB48 | chr1 | 6649165 | + | ARHGEF39 | chr9 | 35675565 | - |
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FusionProtFeatures for ZBTB48_ARHGEF39 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB48 | ARHGEF39 |