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Fusion gene ID: 42516 |
FusionGeneSummary for ZBTB46_MAFB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB46_MAFB | Fusion gene ID: 42516 | Hgene | Tgene | Gene symbol | ZBTB46 | MAFB | Gene ID | 140685 | 9935 |
| Gene name | zinc finger and BTB domain containing 46 | MAF bZIP transcription factor B | |
| Synonyms | BTBD4|BZEL|RINZF|ZNF340|dJ583P15.7|dJ583P15.8 | DURS3|KRML|MCTO | |
| Cytomap | 20q13.33 | 20q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 46BTB (POZ) domain containing 4BTB-ZF protein expressed in effector lymphocytesBTB/POZ domain-containing protein 4zinc finger protein 340 | transcription factor MafBKreisler maf-related leucine zipper homologMAFB/Kreisler basic region/leucine zipper transcription factorv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q86UZ6 | Q9Y5Q3 | |
| Ensembl transtripts involved in fusion gene | ENST00000245663, ENST00000395104, ENST00000302995, ENST00000480766, | ENST00000373313, ENST00000396967, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZBTB46 [Title/Abstract] AND MAFB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAFB | GO:0045647 | negative regulation of erythrocyte differentiation | 8620536 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD699168 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000245663 | ENST00000373313 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-intron | ENST00000245663 | ENST00000396967 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-3UTR | ENST00000395104 | ENST00000373313 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-intron | ENST00000395104 | ENST00000396967 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-3UTR | ENST00000302995 | ENST00000373313 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-intron | ENST00000302995 | ENST00000396967 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-3UTR | ENST00000480766 | ENST00000373313 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
| intron-intron | ENST00000480766 | ENST00000396967 | ZBTB46 | chr20 | 62375756 | + | MAFB | chr20 | 39315012 | - |
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FusionProtFeatures for ZBTB46_MAFB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB46 | MAFB |