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Fusion gene ID: 42496 |
FusionGeneSummary for ZBTB2_AKAP12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB2_AKAP12 | Fusion gene ID: 42496 | Hgene | Tgene | Gene symbol | ZBTB2 | AKAP12 | Gene ID | 57621 | 9590 |
| Gene name | zinc finger and BTB domain containing 2 | A-kinase anchoring protein 12 | |
| Synonyms | ZNF437 | AKAP250|SSeCKS | |
| Cytomap | 6q25.1 | 6q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 2 | A-kinase anchor protein 12A kinase (PRKA) anchor protein 12A-kinase anchor protein, 250kDaAKAP 250Src-Suppressed C Kinase Substratekinase scaffold protein gravinmyasthenia gravis autoantigen gravin | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N680 | Q02952 | |
| Ensembl transtripts involved in fusion gene | ENST00000325144, | ENST00000402676, ENST00000253332, ENST00000354675, ENST00000359755, ENST00000490177, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZBTB2 [Title/Abstract] AND AKAP12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZBTB2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 19380588 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-HU-A4H8-01A | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000325144 | ENST00000402676 | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
| Frame-shift | ENST00000325144 | ENST00000253332 | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
| Frame-shift | ENST00000325144 | ENST00000354675 | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
| Frame-shift | ENST00000325144 | ENST00000359755 | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
| 5CDS-3UTR | ENST00000325144 | ENST00000490177 | ZBTB2 | chr6 | 151694600 | - | AKAP12 | chr6 | 151669846 | + |
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FusionProtFeatures for ZBTB2_AKAP12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB2 | AKAP12 |