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Fusion gene ID: 42495 |
FusionGeneSummary for ZBTB25_TPRG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB25_TPRG1 | Fusion gene ID: 42495 | Hgene | Tgene | Gene symbol | ZBTB25 | TPRG1 | Gene ID | 7597 | 285386 |
| Gene name | zinc finger and BTB domain containing 25 | tumor protein p63 regulated 1 | |
| Synonyms | C14orf51|KUP|ZNF46 | FAM79B | |
| Cytomap | 14q23.3 | 3q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 25zinc finger protein 46zinc finger protein KUP | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | P24278 | Q6ZUI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000555220, ENST00000555424, ENST00000608382, ENST00000394715, | ENST00000433971, ENST00000345063, ENST00000488841, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 12 X 6 X 6=432 |
| # samples | 3 | 13 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZBTB25 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-L3-A524-01A | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000555220 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-3CDS | ENST00000555220 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-intron | ENST00000555220 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-3CDS | ENST00000555424 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-3CDS | ENST00000555424 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-intron | ENST00000555424 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| 5UTR-3CDS | ENST00000608382 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| 5UTR-3CDS | ENST00000608382 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| 5UTR-intron | ENST00000608382 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-3CDS | ENST00000394715 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-3CDS | ENST00000394715 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
| intron-intron | ENST00000394715 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
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FusionProtFeatures for ZBTB25_TPRG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB25 | TPRG1 |