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Fusion gene ID: 42453 |
FusionGeneSummary for ZBED6_FIP1L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBED6_FIP1L1 | Fusion gene ID: 42453 | Hgene | Tgene | Gene symbol | ZBED6 | FIP1L1 | Gene ID | 100381270 | 81608 |
| Gene name | zinc finger BED-type containing 6 | factor interacting with PAPOLA and CPSF1 | |
| Synonyms | MGR | FIP1|Rhe|hFip1 | |
| Cytomap | 1q32.1 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger BED domain-containing protein 6 | pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P86452 | Q6UN15 | |
| Ensembl transtripts involved in fusion gene | ENST00000550078, | ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 10 X 5=450 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZBED6 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-E1-A7YD-01A | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000550078 | ENST00000507166 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| intron-3CDS | ENST00000550078 | ENST00000358575 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| intron-3CDS | ENST00000550078 | ENST00000337488 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| intron-3CDS | ENST00000550078 | ENST00000507922 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| intron-3CDS | ENST00000550078 | ENST00000306932 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
| intron-intron | ENST00000550078 | ENST00000510668 | ZBED6 | chr1 | 203787817 | + | FIP1L1 | chr4 | 54292039 | + |
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FusionProtFeatures for ZBED6_FIP1L1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBED6 | FIP1L1 |