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Fusion gene ID: 42448 |
FusionGeneSummary for ZBED4_DCTN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBED4_DCTN1 | Fusion gene ID: 42448 | Hgene | Tgene | Gene symbol | ZBED4 | DCTN1 | Gene ID | 9889 | 1639 |
| Gene name | zinc finger BED-type containing 4 | dynactin subunit 1 | |
| Synonyms | - | DAP-150|DP-150|P135 | |
| Cytomap | 22q13.33 | 2p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger BED domain-containing protein 4zinc finger, BED domain containing 4 | dynactin subunit 1150 kDa dynein-associated polypeptidedynactin 1 (p150, glued homolog, Drosophila) | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O75132 | Q14203 | |
| Ensembl transtripts involved in fusion gene | ENST00000216268, | ENST00000394003, ENST00000361874, ENST00000407639, ENST00000409438, ENST00000409240, ENST00000409868, ENST00000409567, ENST00000495643, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 3 X 3 X 1=9 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZBED4 [Title/Abstract] AND DCTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DCTN1 | GO:0031116 | positive regulation of microtubule polymerization | 23874158 |
| Tgene | DCTN1 | GO:0090063 | positive regulation of microtubule nucleation | 23874158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB293431 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000216268 | ENST00000394003 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-intron | ENST00000216268 | ENST00000361874 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-intron | ENST00000216268 | ENST00000407639 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-intron | ENST00000216268 | ENST00000409438 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-5UTR | ENST00000216268 | ENST00000409240 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-5UTR | ENST00000216268 | ENST00000409868 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-intron | ENST00000216268 | ENST00000409567 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
| 5CDS-intron | ENST00000216268 | ENST00000495643 | ZBED4 | chr22 | 50277430 | + | DCTN1 | chr2 | 74618972 | - |
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FusionProtFeatures for ZBED4_DCTN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBED4 | DCTN1 |