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Fusion gene ID: 42434 |
FusionGeneSummary for YY1AP1_MLXIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YY1AP1_MLXIP | Fusion gene ID: 42434 | Hgene | Tgene | Gene symbol | YY1AP1 | MLXIP | Gene ID | 55249 | 22877 |
| Gene name | YY1 associated protein 1 | MLX interacting protein | |
| Synonyms | GRNG|HCCA1|HCCA2|YY1AP | MIR|MONDOA|bHLHe36 | |
| Cytomap | 1q22 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2 | MLX-interacting proteinMlx interactorclass E basic helix-loop-helix protein 36transcriptional activator MondoA | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9H869 | Q9HAP2 | |
| Ensembl transtripts involved in fusion gene | ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093, | ENST00000319080, ENST00000538698, ENST00000377037, ENST00000535996, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 7 X 6 X 4=168 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: YY1AP1 [Title/Abstract] AND MLXIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YY1AP1 | GO:0051726 | regulation of cell cycle | 17541814 |
| Tgene | MLXIP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11073985 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI004450 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000311573 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000311573 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000311573 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000311573 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000368340 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000368340 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368340 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368340 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000347088 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000347088 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000347088 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000347088 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000361831 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000361831 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000361831 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000361831 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000355499 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000355499 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000355499 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000355499 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000404643 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000404643 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000404643 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000404643 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000407221 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000407221 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000407221 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000407221 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000359205 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000359205 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000359205 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000359205 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000295566 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000295566 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000295566 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000295566 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000368330 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000368330 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368330 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368330 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000368339 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000368339 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368339 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000368339 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000535662 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000535662 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000535662 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000535662 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000405763 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000405763 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000405763 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000405763 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000438245 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000438245 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000438245 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000438245 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-3CDS | ENST00000476093 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-5UTR | ENST00000476093 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000476093 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
| intron-intron | ENST00000476093 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
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FusionProtFeatures for YY1AP1_MLXIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YY1AP1 | MLXIP |