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Fusion gene ID: 4242 |
FusionGeneSummary for BMP7_PLD6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BMP7_PLD6 | Fusion gene ID: 4242 | Hgene | Tgene | Gene symbol | BMP7 | PLD6 | Gene ID | 655 | 201164 |
| Gene name | bone morphogenetic protein 7 | phospholipase D family member 6 | |
| Synonyms | OP-1 | ZUC | |
| Cytomap | 20q13.31 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bone morphogenetic protein 7osteogenic protein 1 | mitochondrial cardiolipin hydrolasePLD 6choline phosphatase 6mitoPLDmitochondrial phospholipasephosphatidylcholine-hydrolyzing phospholipase D6phospholipase D6protein zucchini homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P18075 | Q8N2A8 | |
| Ensembl transtripts involved in fusion gene | ENST00000395863, ENST00000395864, ENST00000450594, ENST00000460817, | ENST00000321560, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BMP7 [Title/Abstract] AND PLD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BMP7 | GO:0010628 | positive regulation of gene expression | 28124060 |
| Hgene | BMP7 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 19736306 |
| Hgene | BMP7 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 9311995|16049014|17244894|19736306 |
| Hgene | BMP7 | GO:0030501 | positive regulation of bone mineralization | 18436533 |
| Hgene | BMP7 | GO:0030509 | BMP signaling pathway | 16049014|18436533 |
| Hgene | BMP7 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 15100360 |
| Hgene | BMP7 | GO:0034504 | protein localization to nucleus | 17244894 |
| Hgene | BMP7 | GO:0042326 | negative regulation of phosphorylation | 17244894 |
| Hgene | BMP7 | GO:0043407 | negative regulation of MAP kinase activity | 17244894 |
| Hgene | BMP7 | GO:0045665 | negative regulation of neuron differentiation | 16325379 |
| Hgene | BMP7 | GO:0045669 | positive regulation of osteoblast differentiation | 18436533 |
| Hgene | BMP7 | GO:0045786 | negative regulation of cell cycle | 11502704 |
| Hgene | BMP7 | GO:0045839 | negative regulation of mitotic nuclear division | 17244894 |
| Hgene | BMP7 | GO:0045892 | negative regulation of transcription, DNA-templated | 15100360|17244894 |
| Hgene | BMP7 | GO:0045893 | positive regulation of transcription, DNA-templated | 14517293|15100360|16049014 |
| Hgene | BMP7 | GO:0048762 | mesenchymal cell differentiation | 9693150 |
| Hgene | BMP7 | GO:0048812 | neuron projection morphogenesis | 16325379 |
| Hgene | BMP7 | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation | 16049014 |
| Hgene | BMP7 | GO:0060395 | SMAD protein signal transduction | 17244894 |
| Hgene | BMP7 | GO:0060548 | negative regulation of cell death | 12631064 |
| Hgene | BMP7 | GO:0070487 | monocyte aggregation | 15100360 |
| Hgene | BMP7 | GO:0072125 | negative regulation of glomerular mesangial cell proliferation | 17244894 |
| Hgene | BMP7 | GO:1900006 | positive regulation of dendrite development | 11580864 |
| Hgene | BMP7 | GO:1900106 | positive regulation of hyaluranon cable assembly | 15100360 |
| Tgene | PLD6 | GO:0010636 | positive regulation of mitochondrial fusion | 24599962 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI053091 | BMP7 | chr20 | 55745997 | - | PLD6 | chr17 | 17134833 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000395863 | ENST00000321560 | BMP7 | chr20 | 55745997 | - | PLD6 | chr17 | 17134833 | - |
| intron-intron | ENST00000395864 | ENST00000321560 | BMP7 | chr20 | 55745997 | - | PLD6 | chr17 | 17134833 | - |
| intron-intron | ENST00000450594 | ENST00000321560 | BMP7 | chr20 | 55745997 | - | PLD6 | chr17 | 17134833 | - |
| intron-intron | ENST00000460817 | ENST00000321560 | BMP7 | chr20 | 55745997 | - | PLD6 | chr17 | 17134833 | - |
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FusionProtFeatures for BMP7_PLD6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BMP7 | PLD6 |