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Fusion gene ID: 4227 |
FusionGeneSummary for BMP1_MALL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BMP1_MALL | Fusion gene ID: 4227 | Hgene | Tgene | Gene symbol | BMP1 | MALL | Gene ID | 649 | 7851 |
| Gene name | bone morphogenetic protein 1 | mal, T cell differentiation protein like | |
| Synonyms | OI13|PCOLC|PCP|PCP2|TLD | BENE | |
| Cytomap | 8p21.3 | 2q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bone morphogenetic protein 1mammalian tolloid proteinprocollagen C-endopeptidaseprocollagen C-proteinase 3 | MAL-like protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P13497 | Q13021 | |
| Ensembl transtripts involved in fusion gene | ENST00000306385, ENST00000354870, ENST00000397816, ENST00000306349, ENST00000397814, ENST00000523849, | ENST00000272462, ENST00000427178, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BMP1 [Title/Abstract] AND MALL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BMP1 | GO:0006508 | proteolysis | 16824737 |
| Hgene | BMP1 | GO:0061036 | positive regulation of cartilage development | 3201241 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF737796 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000306385 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-intron | ENST00000306385 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 3UTR-3UTR | ENST00000354870 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 3UTR-intron | ENST00000354870 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-3UTR | ENST00000397816 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-intron | ENST00000397816 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-3UTR | ENST00000306349 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-intron | ENST00000306349 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-3UTR | ENST00000397814 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| 5CDS-intron | ENST00000397814 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| intron-3UTR | ENST00000523849 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
| intron-intron | ENST00000523849 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
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FusionProtFeatures for BMP1_MALL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BMP1 | MALL |