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Fusion gene ID: 42245 |
FusionGeneSummary for XRRA1_SHANK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XRRA1_SHANK2 | Fusion gene ID: 42245 | Hgene | Tgene | Gene symbol | XRRA1 | SHANK2 | Gene ID | 143570 | 22941 |
| Gene name | X-ray radiation resistance associated 1 | SH3 and multiple ankyrin repeat domains 2 | |
| Synonyms | - | AUTS17|CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3 | |
| Cytomap | 11q13.4 | 11q13.3-q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | X-ray radiation resistance-associated protein 1 | SH3 and multiple ankyrin repeat domains protein 2GKAP/SAPAP interacting proteincortactin SH3 domain-binding proteincortactin-binding protein 1proline-rich synapse associated protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6P2D8 | Q9UPX8 | |
| Ensembl transtripts involved in fusion gene | ENST00000340360, ENST00000321448, ENST00000527087, ENST00000533598, | ENST00000449833, ENST00000409161, ENST00000423696, ENST00000338508, ENST00000409530, ENST00000449116, ENST00000357171, ENST00000468619, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 27 X 15 X 8=3240 |
| # samples | 6 | 30 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/3240*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: XRRA1 [Title/Abstract] AND SHANK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | XRRA1 | GO:0010165 | response to X-ray | 12908878 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2Y-A9GS-01A | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000340360 | ENST00000449833 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000409161 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000423696 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000338508 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000409530 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000449116 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000357171 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000340360 | ENST00000468619 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000449833 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000409161 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000423696 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000338508 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000409530 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000449116 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000357171 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000321448 | ENST00000468619 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000449833 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000409161 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000423696 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000338508 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000409530 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000449116 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000357171 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5CDS-intron | ENST00000527087 | ENST00000468619 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000449833 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000409161 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000423696 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000338508 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000409530 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000449116 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000357171 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
| 5UTR-intron | ENST00000533598 | ENST00000468619 | XRRA1 | chr11 | 74641345 | - | SHANK2 | chr11 | 70821095 | - |
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FusionProtFeatures for XRRA1_SHANK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XRRA1 | SHANK2 |