|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 42234 |
FusionGeneSummary for XRN1_PRKCE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XRN1_PRKCE | Fusion gene ID: 42234 | Hgene | Tgene | Gene symbol | XRN1 | PRKCE | Gene ID | 54464 | 5581 |
| Gene name | 5'-3' exoribonuclease 1 | protein kinase C epsilon | |
| Synonyms | SEP1 | PKCE|nPKC-epsilon | |
| Cytomap | 3q23 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-3' exoribonuclease 1strand-exchange protein 1 homolog | protein kinase C epsilon type | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZH2 | Q02156 | |
| Ensembl transtripts involved in fusion gene | ENST00000264951, ENST00000392981, ENST00000463916, ENST00000544157, ENST00000465074, | ENST00000306156, ENST00000467135, ENST00000394874, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 8 X 9 X 4=288 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: XRN1 [Title/Abstract] AND PRKCE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCE | GO:0006468 | protein phosphorylation | 18556656 |
| Tgene | PRKCE | GO:0018105 | peptidyl-serine phosphorylation | 15695813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-69-7979-01A | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000264951 | ENST00000306156 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| 5CDS-intron | ENST00000264951 | ENST00000467135 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| 5CDS-intron | ENST00000264951 | ENST00000394874 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| Frame-shift | ENST00000392981 | ENST00000306156 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| 5CDS-intron | ENST00000392981 | ENST00000467135 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| 5CDS-intron | ENST00000392981 | ENST00000394874 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-3CDS | ENST00000463916 | ENST00000306156 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000463916 | ENST00000467135 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000463916 | ENST00000394874 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-3CDS | ENST00000544157 | ENST00000306156 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000544157 | ENST00000467135 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000544157 | ENST00000394874 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-3CDS | ENST00000465074 | ENST00000306156 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000465074 | ENST00000467135 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
| intron-intron | ENST00000465074 | ENST00000394874 | XRN1 | chr3 | 142089327 | - | PRKCE | chr2 | 46411874 | + |
Top |
FusionProtFeatures for XRN1_PRKCE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XRN1 | PRKCE |