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Fusion gene ID: 42221 |
FusionGeneSummary for XRCC5_ACADL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XRCC5_ACADL | Fusion gene ID: 42221 | Hgene | Tgene | Gene symbol | XRCC5 | ACADL | Gene ID | 7520 | 33 |
| Gene name | X-ray repair cross complementing 5 | acyl-CoA dehydrogenase long chain | |
| Synonyms | KARP-1|KARP1|KU80|KUB2|Ku86|NFIV | ACAD4|LCAD | |
| Cytomap | 2q35 | 2q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | X-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKu | long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, long chain | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P13010 | P28330 | |
| Ensembl transtripts involved in fusion gene | ENST00000392133, ENST00000392132, ENST00000471649, | ENST00000233710, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: XRCC5 [Title/Abstract] AND ACADL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | XRCC5 | GO:0002218 | activation of innate immune response | 28712728 |
| Hgene | XRCC5 | GO:0006303 | double-strand break repair via nonhomologous end joining | 26359349 |
| Hgene | XRCC5 | GO:0045860 | positive regulation of protein kinase activity | 22504299 |
| Hgene | XRCC5 | GO:0071480 | cellular response to gamma radiation | 26359349 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IH-01A | XRCC5 | chr2 | 217059709 | + | ACADL | chr2 | 211060062 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392133 | ENST00000233710 | XRCC5 | chr2 | 217059709 | + | ACADL | chr2 | 211060062 | - |
| In-frame | ENST00000392132 | ENST00000233710 | XRCC5 | chr2 | 217059709 | + | ACADL | chr2 | 211060062 | - |
| intron-3CDS | ENST00000471649 | ENST00000233710 | XRCC5 | chr2 | 217059709 | + | ACADL | chr2 | 211060062 | - |
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FusionProtFeatures for XRCC5_ACADL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XRCC5 | ACADL |