	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 42115

FusionGeneSummary for WWOX_VAT1L

Fusion gene summary

Fusion gene information	Fusion gene name: WWOX_VAT1L
	Fusion gene ID: 42115
		Hgene	Tgene
	Gene symbol	WWOX	VAT1L
	Gene ID	51741	57687
	Gene name	WW domain containing oxidoreductase	vesicle amine transport 1 like
	Synonyms	D16S432E\|EIEE28\|FOR\|FRA16D\|HHCMA56\|PRO0128\|SCAR12\|SDR41C1\|WOX1	-
	Cytomap	16q23.1-q23.2	16q23.1
	Type of gene	protein-coding	protein-coding
	Description	WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1	synaptic vesicle membrane protein VAT-1 homolog-likevesicle amine transport protein 1 homolog (T. californica)-likevesicle amine transport protein 1 homolog-like (T. californica)
	Modification date	20180523	20180519
	UniProtAcc	Q9NZC7	Q9HCJ6
	Ensembl transtripts involved in fusion gene	ENST00000566780, ENST00000406884, ENST00000539474, ENST00000402655, ENST00000408984, ENST00000355860, ENST00000565791, ENST00000569818,	ENST00000302536, ENST00000563850,
Fusion gene scores	* DoF score	9 X 10 X 7=630	3 X 4 X 3=36
	# samples	14	4
	** MAII score	log2(14/630*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: WWOX [Title/Abstract] AND VAT1L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	WWOX	GO:0030178	negative regulation of Wnt signaling pathway	19465938
Hgene	WWOX	GO:0071560	cellular response to transforming growth factor beta stimulus	19366691

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	COAD	TCGA-A6-4105-01A	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
TCGA	RV	STAD	TCGA-CD-8535-01A	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000566780	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000566780	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
In-frame	ENST00000406884	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000406884	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000539474	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-intron	ENST00000539474	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000402655	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-intron	ENST00000402655	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
In-frame	ENST00000408984	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000408984	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
In-frame	ENST00000355860	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000355860	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
3UTR-3CDS	ENST00000565791	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
3UTR-intron	ENST00000565791	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000569818	ENST00000302536	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
intron-intron	ENST00000569818	ENST00000563850	WWOX	chr16	78198186	+	VAT1L	chr16	78005747	+
In-frame	ENST00000566780	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000566780	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
In-frame	ENST00000406884	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000406884	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
In-frame	ENST00000539474	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000539474	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
In-frame	ENST00000402655	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000402655	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
In-frame	ENST00000408984	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000408984	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
In-frame	ENST00000355860	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000355860	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
intron-3CDS	ENST00000565791	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
intron-intron	ENST00000565791	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
Frame-shift	ENST00000569818	ENST00000302536	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+
5CDS-intron	ENST00000569818	ENST00000563850	WWOX	chr16	78133782	+	VAT1L	chr16	77850818	+

Top

FusionProtFeatures for WWOX_VAT1L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
WWOX Q9NZC7	VAT1L Q9HCJ6

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 42115

FusionGeneSummary for WWOX_VAT1L

FusionProtFeatures for WWOX_VAT1L