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Fusion gene ID: 42105 |
FusionGeneSummary for WWC2_CCDC110 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WWC2_CCDC110 | Fusion gene ID: 42105 | Hgene | Tgene | Gene symbol | WWC2 | CCDC110 | Gene ID | 80014 | 256309 |
| Gene name | WW and C2 domain containing 2 | coiled-coil domain containing 110 | |
| Synonyms | BOMB | CT52|KM-HN-1|KMHN1 | |
| Cytomap | 4q35.1 | 4q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein WWC2BH3-only member B proteinWW, C2 and coiled-coil domain containing 2 | coiled-coil domain-containing protein 110cancer/testis antigen 52cancer/testis antigen KM-HN-1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6AWC2 | Q8TBZ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000403733, ENST00000378925, ENST00000513834, ENST00000448232, ENST00000504005, ENST00000506225, ENST00000508747, | ENST00000393540, ENST00000307588, ENST00000510617, ENST00000507501, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 4 X 3=36 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: WWC2 [Title/Abstract] AND CCDC110 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WWC2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24682284 |
| Hgene | WWC2 | GO:0035331 | negative regulation of hippo signaling | 24682284 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-H7-A6C4-01A | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000403733 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000403733 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000403733 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5CDS-5UTR | ENST00000403733 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5UTR-3CDS | ENST00000378925 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5UTR-3CDS | ENST00000378925 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5UTR-3CDS | ENST00000378925 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5UTR-5UTR | ENST00000378925 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000513834 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000513834 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000513834 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5CDS-5UTR | ENST00000513834 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000448232 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000448232 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| Frame-shift | ENST00000448232 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| 5CDS-5UTR | ENST00000448232 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000504005 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000504005 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000504005 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-5UTR | ENST00000504005 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000506225 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000506225 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000506225 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-5UTR | ENST00000506225 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000508747 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000508747 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-3CDS | ENST00000508747 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
| intron-5UTR | ENST00000508747 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
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FusionProtFeatures for WWC2_CCDC110 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WWC2 | CCDC110 |