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Fusion gene ID: 42043 |
FusionGeneSummary for WNK1_PRMT8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WNK1_PRMT8 | Fusion gene ID: 42043 | Hgene | Tgene | Gene symbol | WNK1 | PRMT8 | Gene ID | 65125 | 56341 |
| Gene name | WNK lysine deficient protein kinase 1 | protein arginine methyltransferase 8 | |
| Synonyms | HSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65 | HRMT1L3|HRMT1L4 | |
| Cytomap | 12p13.33 | 12p13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki | protein arginine N-methyltransferase 8HMT1 hnRNP methyltransferase-like 3arginine methyltransferase 8heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4protein arginine N-methyltransferase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H4A3 | Q9NR22 | |
| Ensembl transtripts involved in fusion gene | ENST00000535572, ENST00000537687, ENST00000315939, ENST00000447667, ENST00000530271, ENST00000540360, ENST00000340908, ENST00000574564, | ENST00000452611, ENST00000382622, ENST00000261252, | |
| Fusion gene scores | * DoF score | 15 X 10 X 10=1500 | 4 X 3 X 3=36 |
| # samples | 19 | 4 | |
| ** MAII score | log2(19/1500*10)=-2.9808911770523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: WNK1 [Title/Abstract] AND PRMT8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WNK1 | GO:0006468 | protein phosphorylation | 10660600 |
| Hgene | WNK1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Hgene | WNK1 | GO:0023016 | signal transduction by trans-phosphorylation | 16669787 |
| Hgene | WNK1 | GO:0035556 | intracellular signal transduction | 10660600 |
| Tgene | PRMT8 | GO:0016571 | histone methylation | 16051612 |
| Tgene | PRMT8 | GO:0018216 | peptidyl-arginine methylation | 16051612|18320585 |
| Tgene | PRMT8 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | 16051612 |
| Tgene | PRMT8 | GO:0051260 | protein homooligomerization | 26876602 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A18T-01A | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000535572 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000535572 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| 5CDS-3UTR | ENST00000535572 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000537687 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000537687 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| 5CDS-3UTR | ENST00000537687 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000315939 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000315939 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| 5CDS-3UTR | ENST00000315939 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000447667 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000447667 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3UTR | ENST00000447667 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000530271 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000530271 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| 5CDS-3UTR | ENST00000530271 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000540360 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000540360 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3UTR | ENST00000540360 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000340908 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| In-frame | ENST00000340908 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| 5CDS-3UTR | ENST00000340908 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000574564 | ENST00000452611 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3CDS | ENST00000574564 | ENST00000382622 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
| intron-3UTR | ENST00000574564 | ENST00000261252 | WNK1 | chr12 | 971436 | + | PRMT8 | chr12 | 3649772 | + |
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FusionProtFeatures for WNK1_PRMT8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WNK1 | PRMT8 |