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Fusion gene ID: 4203 |
FusionGeneSummary for BLCAP_FTH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BLCAP_FTH1 | Fusion gene ID: 4203 | Hgene | Tgene | Gene symbol | BLCAP | FTH1 | Gene ID | 10904 | 2495 |
| Gene name | BLCAP, apoptosis inducing factor | ferritin heavy chain 1 | |
| Synonyms | BC10 | FHC|FTH|FTHL6|HFE5|PIG15|PLIF | |
| Cytomap | 20q11.23 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bladder cancer-associated proteinbladder cancer associated proteinbladder cancer related protein (10kD) | ferritin heavy chainapoferritincell proliferation-inducing gene 15 proteinferritin H subunitferritin, heavy polypeptide 1placenta immunoregulatory factorproliferation-inducing protein 15 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P62952 | P02794 | |
| Ensembl transtripts involved in fusion gene | ENST00000411780, ENST00000397137, ENST00000373537, ENST00000414542, ENST00000397135, ENST00000397134, ENST00000397131, | ENST00000529631, ENST00000529191, ENST00000273550, ENST00000526640, ENST00000532601, | |
| Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 5 X 5 X 1=25 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BLCAP [Title/Abstract] AND FTH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BLCAP | GO:0030262 | apoptotic nuclear changes | 17031575 |
| Tgene | FTH1 | GO:0006880 | intracellular sequestering of iron ion | 9924025 |
| Tgene | FTH1 | GO:0048147 | negative regulation of fibroblast proliferation | 9924025 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC001481 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000411780 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000411780 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000411780 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000411780 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000411780 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397137 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397137 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397137 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397137 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397137 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000373537 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000373537 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000373537 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000373537 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000373537 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000414542 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000414542 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000414542 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000414542 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000414542 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397135 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397135 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397135 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397135 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397135 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397134 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397134 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397134 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397134 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397134 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397131 | ENST00000529631 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397131 | ENST00000529191 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-5UTR | ENST00000397131 | ENST00000273550 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397131 | ENST00000526640 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
| intron-intron | ENST00000397131 | ENST00000532601 | BLCAP | chr20 | 36146457 | - | FTH1 | chr11 | 61735089 | - |
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FusionProtFeatures for BLCAP_FTH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BLCAP | FTH1 |