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Fusion gene ID: 42021 |
FusionGeneSummary for WIPF2_TMEM99 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WIPF2_TMEM99 | Fusion gene ID: 42021 | Hgene | Tgene | Gene symbol | WIPF2 | TMEM99 | Gene ID | 147179 | 147184 |
| Gene name | WAS/WASL interacting protein family member 2 | transmembrane protein 99 | |
| Synonyms | WICH|WIRE | - | |
| Cytomap | 17q21.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein | transmembrane protein 99 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q8TF74 | Q8N816 | |
| Ensembl transtripts involved in fusion gene | ENST00000494757, ENST00000323571, ENST00000585043, ENST00000394103, ENST00000536600, ENST00000583130, | ENST00000301665, ENST00000496847, | |
| Fusion gene scores | * DoF score | 28 X 7 X 15=2940 | 4 X 1 X 3=12 |
| # samples | 28 | 4 | |
| ** MAII score | log2(28/2940*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: WIPF2 [Title/Abstract] AND TMEM99 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-2H-A9GI-01A | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000494757 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| intron-intron | ENST00000494757 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-5UTR | ENST00000323571 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-intron | ENST00000323571 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-5UTR | ENST00000585043 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-intron | ENST00000585043 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-5UTR | ENST00000394103 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-intron | ENST00000394103 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-5UTR | ENST00000536600 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-intron | ENST00000536600 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-5UTR | ENST00000583130 | ENST00000301665 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
| 5CDS-intron | ENST00000583130 | ENST00000496847 | WIPF2 | chr17 | 38412774 | + | TMEM99 | chr17 | 38989367 | + |
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FusionProtFeatures for WIPF2_TMEM99 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WIPF2 | TMEM99 |