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Fusion gene ID: 41849 |
FusionGeneSummary for WDR44_DOCK11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDR44_DOCK11 | Fusion gene ID: 41849 | Hgene | Tgene | Gene symbol | WDR44 | DOCK11 | Gene ID | 54521 | 139818 |
| Gene name | WD repeat domain 44 | dedicator of cytokinesis 11 | |
| Synonyms | RAB11BP|RPH11|SYM-4 | ACG|ZIZ2|bB128O4.1 | |
| Cytomap | Xq24 | Xq24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat-containing protein 44rabphilin-11 | dedicator of cytokinesis protein 11Activated Cdc42-associated guanine nucleotide exchange factor, ACGbB128O4.1.1 (novel protein)zizimin-2zizimin2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5JSH3 | Q5JSL3 | |
| Ensembl transtripts involved in fusion gene | ENST00000371822, ENST00000254029, ENST00000371825, ENST00000493448, | ENST00000276204, ENST00000276202, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 6=216 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WDR44 [Title/Abstract] AND DOCK11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-VR-A8EW-01A | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371822 | ENST00000276204 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| In-frame | ENST00000371822 | ENST00000276202 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| In-frame | ENST00000254029 | ENST00000276204 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| In-frame | ENST00000254029 | ENST00000276202 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| In-frame | ENST00000371825 | ENST00000276204 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| In-frame | ENST00000371825 | ENST00000276202 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| intron-3CDS | ENST00000493448 | ENST00000276204 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
| intron-3CDS | ENST00000493448 | ENST00000276202 | WDR44 | chrX | 117544922 | + | DOCK11 | chrX | 117758502 | + |
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FusionProtFeatures for WDR44_DOCK11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDR44 | DOCK11 |