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Fusion gene ID: 41840 |
FusionGeneSummary for WDR37_FAM107B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDR37_FAM107B | Fusion gene ID: 41840 | Hgene | Tgene | Gene symbol | WDR37 | FAM107B | Gene ID | 22884 | 83641 |
| Gene name | WD repeat domain 37 | family with sequence similarity 107 member B | |
| Synonyms | - | C10orf45|HITS | |
| Cytomap | 10p15.3 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat-containing protein 37 | protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y2I8 | Q9H098 | |
| Ensembl transtripts involved in fusion gene | ENST00000358220, ENST00000381329, ENST00000263150, ENST00000482165, | ENST00000181796, ENST00000378470, ENST00000468747, ENST00000378467, ENST00000378465, ENST00000378458, ENST00000478076, ENST00000378462, ENST00000496330, ENST00000479731, ENST00000471815, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 9 X 7 X 6=378 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WDR37 [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-CU-A3QU-01A | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000358220 | ENST00000181796 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000378470 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000468747 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000378467 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000378465 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000378458 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000478076 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000378462 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000496330 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000479731 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000358220 | ENST00000471815 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| Frame-shift | ENST00000381329 | ENST00000181796 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000378470 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000468747 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000378467 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000378465 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000378458 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000478076 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000378462 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000496330 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000479731 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000381329 | ENST00000471815 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| In-frame | ENST00000263150 | ENST00000181796 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000378470 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000468747 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000378467 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000378465 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000378458 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000478076 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000378462 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000496330 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000479731 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| 5CDS-intron | ENST00000263150 | ENST00000471815 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-3CDS | ENST00000482165 | ENST00000181796 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000378470 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000468747 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000378467 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000378465 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000378458 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000478076 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000378462 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000496330 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000479731 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
| intron-intron | ENST00000482165 | ENST00000471815 | WDR37 | chr10 | 1142186 | + | FAM107B | chr10 | 14709690 | - |
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FusionProtFeatures for WDR37_FAM107B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDR37 | FAM107B |