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Fusion gene ID: 41837 |
FusionGeneSummary for WDR35_PUM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDR35_PUM2 | Fusion gene ID: 41837 | Hgene | Tgene | Gene symbol | WDR35 | PUM2 | Gene ID | 57539 | 23369 |
| Gene name | WD repeat domain 35 | pumilio RNA binding family member 2 | |
| Synonyms | CED2|IFT121|IFTA1|SRTD7 | PUMH2|PUML2 | |
| Cytomap | 2p24.1 | 2p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat-containing protein 35intraflagellar transport protein 121 homolognaofen | pumilio homolog 2pumilio-2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9P2L0 | Q8TB72 | |
| Ensembl transtripts involved in fusion gene | ENST00000281405, ENST00000345530, ENST00000416055, | ENST00000338086, ENST00000319801, ENST00000361078, ENST00000536417, ENST00000403432, ENST00000420234, | |
| Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 8 X 7 X 5=280 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WDR35 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PUM2 | GO:0010608 | posttranscriptional regulation of gene expression | 25100735 |
| Tgene | PUM2 | GO:0043488 | regulation of mRNA stability | 26724866 |
| Tgene | PUM2 | GO:0051983 | regulation of chromosome segregation | 26724866 |
| Tgene | PUM2 | GO:1900246 | positive regulation of RIG-I signaling pathway | 25340845 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A7-A13D-01A | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| TCGA | RV | LUSC | TCGA-39-5035-01A | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000281405 | ENST00000338086 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000281405 | ENST00000319801 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000281405 | ENST00000361078 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000281405 | ENST00000536417 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000281405 | ENST00000403432 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| 5CDS-intron | ENST00000281405 | ENST00000420234 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000345530 | ENST00000338086 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000345530 | ENST00000319801 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000345530 | ENST00000361078 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000345530 | ENST00000536417 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| In-frame | ENST00000345530 | ENST00000403432 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| 5CDS-intron | ENST00000345530 | ENST00000420234 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000416055 | ENST00000338086 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000416055 | ENST00000319801 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000416055 | ENST00000361078 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000416055 | ENST00000536417 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000416055 | ENST00000403432 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| 5CDS-intron | ENST00000416055 | ENST00000420234 | WDR35 | chr2 | 20130157 | - | PUM2 | chr2 | 20483247 | - |
| Frame-shift | ENST00000281405 | ENST00000338086 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000281405 | ENST00000319801 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000281405 | ENST00000361078 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000281405 | ENST00000536417 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000281405 | ENST00000403432 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| 5CDS-intron | ENST00000281405 | ENST00000420234 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000345530 | ENST00000338086 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000345530 | ENST00000319801 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000345530 | ENST00000361078 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000345530 | ENST00000536417 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| Frame-shift | ENST00000345530 | ENST00000403432 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| 5CDS-intron | ENST00000345530 | ENST00000420234 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| In-frame | ENST00000416055 | ENST00000338086 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| In-frame | ENST00000416055 | ENST00000319801 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| In-frame | ENST00000416055 | ENST00000361078 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| In-frame | ENST00000416055 | ENST00000536417 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| In-frame | ENST00000416055 | ENST00000403432 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
| 5CDS-intron | ENST00000416055 | ENST00000420234 | WDR35 | chr2 | 20151176 | - | PUM2 | chr2 | 20463221 | - |
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FusionProtFeatures for WDR35_PUM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDR35 | PUM2 |