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Fusion gene ID: 4180

FusionGeneSummary for BIRC2_YAP1

Fusion gene summary

Fusion gene information	Fusion gene name: BIRC2_YAP1
	Fusion gene ID: 4180
		Hgene	Tgene
	Gene symbol	BIRC2	YAP1
	Gene ID	329	10413
	Gene name	baculoviral IAP repeat containing 2	Yes associated protein 1
	Synonyms	API1\|HIAP2\|Hiap-2\|MIHB\|RNF48\|c-IAP1\|cIAP1	COB1\|YAP\|YAP2\|YAP65\|YKI
	Cytomap	11q22.2	11q22.1
	Type of gene	protein-coding	protein-coding
	Description	baculoviral IAP repeat-containing protein 2IAP homolog BIAP-2NFR2-TRAF signalling complex proteinRING finger protein 48RING-type E3 ubiquitin transferase BIRC2TNFR2-TRAF-signaling complex protein 2apoptosis inhibitor 1cellular inhibitor of apoptos	transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
	Modification date	20180523	20180527
	UniProtAcc	Q13490	P46937
	Ensembl transtripts involved in fusion gene	ENST00000530675, ENST00000227758, ENST00000532672, ENST00000527910,	ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834,
Fusion gene scores	* DoF score	3 X 3 X 3=27	13 X 7 X 11=1001
	# samples	3	13
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BIRC2 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BIRC2	GO:0000209	protein polyubiquitination	11907583
Hgene	BIRC2	GO:0043066	negative regulation of apoptotic process	21525013
Hgene	BIRC2	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	11907583
Hgene	BIRC2	GO:0051726	regulation of cell cycle	15665297
Hgene	BIRC2	GO:1902523	positive regulation of protein K63-linked ubiquitination	21931591
Hgene	BIRC2	GO:1902524	positive regulation of protein K48-linked ubiquitination	21931591
Hgene	BIRC2	GO:1902527	positive regulation of protein monoubiquitination	21931591
Tgene	YAP1	GO:0006974	cellular response to DNA damage stimulus	18280240
Tgene	YAP1	GO:0008283	cell proliferation	17974916
Tgene	YAP1	GO:0032570	response to progesterone	16772533
Tgene	YAP1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16772533
Tgene	YAP1	GO:0045893	positive regulation of transcription, DNA-templated	20368466
Tgene	YAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	25796446
Tgene	YAP1	GO:0050767	regulation of neurogenesis	25433207
Tgene	YAP1	GO:0050847	progesterone receptor signaling pathway	16772533
Tgene	YAP1	GO:0060242	contact inhibition	17974916
Tgene	YAP1	GO:0065003	protein-containing complex assembly	20368466
Tgene	YAP1	GO:0071480	cellular response to gamma radiation	18280240
Tgene	YAP1	GO:0072091	regulation of stem cell proliferation	25433207

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	STAD	TCGA-CG-4443-01A	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000530675	ENST00000526343	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000530675	ENST00000282441	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000530675	ENST00000537274	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000530675	ENST00000345877	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000530675	ENST00000531439	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000530675	ENST00000524575	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
5CDS-intron	ENST00000530675	ENST00000528834	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000526343	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000282441	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000537274	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000345877	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000531439	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000227758	ENST00000524575	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
5CDS-intron	ENST00000227758	ENST00000528834	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000526343	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000282441	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000537274	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000345877	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000531439	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
In-frame	ENST00000532672	ENST00000524575	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
5CDS-intron	ENST00000532672	ENST00000528834	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000526343	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000282441	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000537274	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000345877	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000531439	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-3CDS	ENST00000527910	ENST00000524575	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+
3UTR-intron	ENST00000527910	ENST00000528834	BIRC2	chr11	102221674	+	YAP1	chr11	102033187	+

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FusionProtFeatures for BIRC2_YAP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BIRC2 Q13490	YAP1 P46937

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Fusion gene ID: 4180

FusionGeneSummary for BIRC2_YAP1

FusionProtFeatures for BIRC2_YAP1