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Fusion gene ID: 41792 |
FusionGeneSummary for WDFY3_ZNF578 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDFY3_ZNF578 | Fusion gene ID: 41792 | Hgene | Tgene | Gene symbol | WDFY3 | ZNF578 | Gene ID | 23001 | 147660 |
| Gene name | WD repeat and FYVE domain containing 3 | zinc finger protein 578 | |
| Synonyms | ALFY|BCHS|MCPH18|ZFYVE25 | - | |
| Cytomap | 4q21.23 | 19q13.41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein | zinc finger protein 578 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZQ1 | Q96N58 | |
| Ensembl transtripts involved in fusion gene | ENST00000322366, ENST00000295888, ENST00000512267, | ENST00000421239, ENST00000596382, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: WDFY3 [Title/Abstract] AND ZNF578 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | R47413 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000322366 | ENST00000421239 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| intron-intron | ENST00000322366 | ENST00000596382 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| intron-intron | ENST00000295888 | ENST00000421239 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| intron-intron | ENST00000295888 | ENST00000596382 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| intron-intron | ENST00000512267 | ENST00000421239 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
| intron-intron | ENST00000512267 | ENST00000596382 | WDFY3 | chr4 | 85634225 | + | ZNF578 | chr19 | 52994298 | + |
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FusionProtFeatures for WDFY3_ZNF578 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDFY3 | ZNF578 |