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Fusion gene ID: 41790 |
FusionGeneSummary for WDFY3_PLAGL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDFY3_PLAGL1 | Fusion gene ID: 41790 | Hgene | Tgene | Gene symbol | WDFY3 | PLAGL1 | Gene ID | 23001 | 5325 |
| Gene name | WD repeat and FYVE domain containing 3 | PLAG1 like zinc finger 1 | |
| Synonyms | ALFY|BCHS|MCPH18|ZFYVE25 | LOT1|ZAC|ZAC1 | |
| Cytomap | 4q21.23 | 6q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein | zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZQ1 | Q9UM63 | |
| Ensembl transtripts involved in fusion gene | ENST00000322366, ENST00000295888, ENST00000512267, | ENST00000429150, ENST00000416623, ENST00000392309, ENST00000392307, ENST00000437412, ENST00000444202, ENST00000493898, ENST00000360537, ENST00000354765, ENST00000367572, ENST00000367571, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 6 X 4 X 4=96 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WDFY3 [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PLAGL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9671765|15888726 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-HB-A3YV-01A | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000322366 | ENST00000429150 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000416623 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000392309 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000392307 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000437412 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000444202 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000493898 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000360537 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000322366 | ENST00000354765 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-intron | ENST00000322366 | ENST00000367572 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-intron | ENST00000322366 | ENST00000367571 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000429150 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000416623 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000392309 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000392307 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000437412 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000444202 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000493898 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000360537 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-5UTR | ENST00000295888 | ENST00000354765 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-intron | ENST00000295888 | ENST00000367572 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| 5UTR-intron | ENST00000295888 | ENST00000367571 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000429150 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000416623 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000392309 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000392307 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000437412 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000444202 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000493898 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000360537 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-5UTR | ENST00000512267 | ENST00000354765 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-intron | ENST00000512267 | ENST00000367572 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
| intron-intron | ENST00000512267 | ENST00000367571 | WDFY3 | chr4 | 85887362 | - | PLAGL1 | chr6 | 144290115 | - |
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FusionProtFeatures for WDFY3_PLAGL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDFY3 | PLAGL1 |