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Fusion gene ID: 41786 |
FusionGeneSummary for WDFY3_FOSL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDFY3_FOSL1 | Fusion gene ID: 41786 | Hgene | Tgene | Gene symbol | WDFY3 | FOSL1 | Gene ID | 23001 | 8061 |
| Gene name | WD repeat and FYVE domain containing 3 | FOS like 1, AP-1 transcription factor subunit | |
| Synonyms | ALFY|BCHS|MCPH18|ZFYVE25 | FRA|FRA1|fra-1 | |
| Cytomap | 4q21.23 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein | fos-related antigen 1FOS like 1, AP-1 trancription factor subunitFOS-like antigen-1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZQ1 | P15407 | |
| Ensembl transtripts involved in fusion gene | ENST00000322366, ENST00000295888, ENST00000512267, | ENST00000448083, ENST00000312562, ENST00000531493, ENST00000532401, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: WDFY3 [Title/Abstract] AND FOSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FOSL1 | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 21673316 |
| Tgene | FOSL1 | GO:2000144 | positive regulation of DNA-templated transcription, initiation | 23027619 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A8IJ-01A | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000322366 | ENST00000448083 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000322366 | ENST00000312562 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000322366 | ENST00000531493 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000322366 | ENST00000532401 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000295888 | ENST00000448083 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000295888 | ENST00000312562 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000295888 | ENST00000531493 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| 5UTR-intron | ENST00000295888 | ENST00000532401 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| intron-intron | ENST00000512267 | ENST00000448083 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| intron-intron | ENST00000512267 | ENST00000312562 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| intron-intron | ENST00000512267 | ENST00000531493 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
| intron-intron | ENST00000512267 | ENST00000532401 | WDFY3 | chr4 | 85853423 | - | FOSL1 | chr11 | 65664477 | - |
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FusionProtFeatures for WDFY3_FOSL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDFY3 | FOSL1 |