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Fusion gene ID: 41733 |
FusionGeneSummary for WARS_EPB41L4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WARS_EPB41L4B | Fusion gene ID: 41733 | Hgene | Tgene | Gene symbol | WARS | EPB41L4B | Gene ID | 7453 | 54566 |
| Gene name | tryptophanyl-tRNA synthetase | erythrocyte membrane protein band 4.1 like 4B | |
| Synonyms | GAMMA-2|HMN9|IFI53|IFP53 | CG1|EHM2 | |
| Cytomap | 14q32.2 | 9q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tryptophan--tRNA ligase, cytoplasmichWRSinterferon-induced protein 53trpRStryptophan tRNA ligase 1, cytoplasmic | band 4.1-like protein 4BFERM-containing protein CG1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P23381 | Q9H329 | |
| Ensembl transtripts involved in fusion gene | ENST00000392882, ENST00000358655, ENST00000355338, ENST00000344102, ENST00000557135, ENST00000556645, ENST00000554084, | ENST00000374566, ENST00000374557, | |
| Fusion gene scores | * DoF score | 8 X 9 X 5=360 | 5 X 4 X 3=60 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WARS [Title/Abstract] AND EPB41L4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WARS | GO:0001933 | negative regulation of protein phosphorylation | 22504299 |
| Hgene | WARS | GO:0006469 | negative regulation of protein kinase activity | 22504299 |
| Hgene | WARS | GO:0010628 | positive regulation of gene expression | 22504299 |
| Hgene | WARS | GO:0010835 | regulation of protein ADP-ribosylation | 22504299 |
| Hgene | WARS | GO:0045765 | regulation of angiogenesis | 11773625|11773626 |
| Tgene | EPB41L4B | GO:0031032 | actomyosin structure organization | 22006950 |
| Tgene | EPB41L4B | GO:0042060 | wound healing | 23664528 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-IN-AB1X-01A | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000392882 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| 5CDS-intron | ENST00000392882 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-3CDS | ENST00000358655 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-intron | ENST00000358655 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| Frame-shift | ENST00000355338 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| 5CDS-intron | ENST00000355338 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-3CDS | ENST00000344102 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-intron | ENST00000344102 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| Frame-shift | ENST00000557135 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| 5CDS-intron | ENST00000557135 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-3CDS | ENST00000556645 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-intron | ENST00000556645 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-3CDS | ENST00000554084 | ENST00000374566 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
| intron-intron | ENST00000554084 | ENST00000374557 | WARS | chr14 | 100835424 | - | EPB41L4B | chr9 | 111979425 | - |
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FusionProtFeatures for WARS_EPB41L4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WARS | EPB41L4B |