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Fusion gene ID: 41721 |
FusionGeneSummary for WARS2_LOXL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WARS2_LOXL2 | Fusion gene ID: 41721 | Hgene | Tgene | Gene symbol | WARS2 | LOXL2 | Gene ID | 10352 | 4017 |
| Gene name | tryptophanyl tRNA synthetase 2, mitochondrial | lysyl oxidase like 2 | |
| Synonyms | NEMMLAS|TrpRS | LOR|LOR2|WS9-14 | |
| Cytomap | 1p12 | 8p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tryptophan--tRNA ligase, mitochondrial(Mt)TrpRStryptophan tRNA ligase 2, mitochondrial | lysyl oxidase homolog 2lysyl oxidase related 2lysyl oxidase-like 2 delta e13lysyl oxidase-like 2 proteinlysyl oxidase-like protein 2lysyl oxidase-related protein 2lysyl oxidase-related protein WS9-14 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UGM6 | Q9Y4K0 | |
| Ensembl transtripts involved in fusion gene | ENST00000369426, ENST00000235521, ENST00000537870, ENST00000497761, | ENST00000389131, ENST00000518472, | |
| Fusion gene scores | * DoF score | 12 X 5 X 10=600 | 4 X 3 X 4=48 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/600*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WARS2 [Title/Abstract] AND LOXL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LOXL2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25959397 |
| Tgene | LOXL2 | GO:0001837 | epithelial to mesenchymal transition | 16096638 |
| Tgene | LOXL2 | GO:0006464 | cellular protein modification process | 23319596 |
| Tgene | LOXL2 | GO:0018057 | peptidyl-lysine oxidation | 25959397|27735137 |
| Tgene | LOXL2 | GO:0045892 | negative regulation of transcription, DNA-templated | 16096638 |
| Tgene | LOXL2 | GO:0046688 | response to copper ion | 23319596 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA579087 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000369426 | ENST00000389131 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-intron | ENST00000369426 | ENST00000518472 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-3CDS | ENST00000235521 | ENST00000389131 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-intron | ENST00000235521 | ENST00000518472 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-3CDS | ENST00000537870 | ENST00000389131 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-intron | ENST00000537870 | ENST00000518472 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-3CDS | ENST00000497761 | ENST00000389131 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
| intron-intron | ENST00000497761 | ENST00000518472 | WARS2 | chr1 | 119683276 | + | LOXL2 | chr8 | 23198691 | - |
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FusionProtFeatures for WARS2_LOXL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WARS2 | LOXL2 |