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Fusion gene ID: 4168 |
FusionGeneSummary for BICD2_ASPN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BICD2_ASPN | Fusion gene ID: 4168 | Hgene | Tgene | Gene symbol | BICD2 | ASPN | Gene ID | 23299 | 54829 |
| Gene name | BICD cargo adaptor 2 | asporin | |
| Synonyms | SMALED2|bA526D8.1 | OS3|PLAP-1|PLAP1|SLRR1C | |
| Cytomap | 9q22.31 | 9q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein bicaudal D homolog 2bic-D 2bicaudal D homolog 2coiled-coil protein BICD2cytoskeleton-like bicaudal D protein homolog 2homolog of Drosophila bicaudal D | asporinasporin (LRR class 1)asporin proteoglycanperiodontal ligament associated protein 1small leucine-rich protein 1C | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8TD16 | Q9BXN1 | |
| Ensembl transtripts involved in fusion gene | ENST00000375512, ENST00000356884, | ENST00000375543, ENST00000375544, ENST00000395538, ENST00000450139, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BICD2 [Title/Abstract] AND ASPN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ASPN | GO:0030282 | bone mineralization | 19589127 |
| Tgene | ASPN | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 17827158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CV-7414-01A | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375512 | ENST00000375543 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| In-frame | ENST00000375512 | ENST00000375544 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| In-frame | ENST00000375512 | ENST00000395538 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| 5CDS-intron | ENST00000375512 | ENST00000450139 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000375543 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000375544 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000395538 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-intron | ENST00000356884 | ENST00000450139 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
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FusionProtFeatures for BICD2_ASPN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BICD2 | ASPN |