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Fusion gene ID: 41647

FusionGeneSummary for VPS8_EIF2AK4

Fusion gene summary

Fusion gene information	Fusion gene name: VPS8_EIF2AK4
	Fusion gene ID: 41647
		Hgene	Tgene
	Gene symbol	VPS8	EIF2AK4
	Gene ID	23355	440275
	Gene name	VPS8, CORVET complex subunit	eukaryotic translation initiation factor 2 alpha kinase 4
	Synonyms	KIAA0804	GCN2\|PVOD2
	Cytomap	3q27.2	15q15.1
	Type of gene	protein-coding	protein-coding
	Description	vacuolar protein sorting-associated protein 8 homologvacuolar protein sorting 8 homolog	eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2
	Modification date	20180519	20180523
	UniProtAcc	Q8N3P4	Q9P2K8
	Ensembl transtripts involved in fusion gene	ENST00000437079, ENST00000287546, ENST00000436792, ENST00000446204, ENST00000424463, ENST00000463687,	ENST00000559624, ENST00000382727, ENST00000263791, ENST00000560648, ENST00000559311,
Fusion gene scores	* DoF score	9 X 5 X 4=180	4 X 6 X 4=96
	# samples	8	7
	** MAII score	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VPS8 [Title/Abstract] AND EIF2AK4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	STAD	TCGA-CG-4449-01A	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000437079	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000437079	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000437079	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000437079	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000437079	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000287546	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000287546	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000287546	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000287546	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000287546	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000436792	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000436792	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000436792	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000436792	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000436792	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000446204	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000446204	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000446204	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000446204	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
5CDS-intron	ENST00000446204	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000424463	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000424463	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000424463	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000424463	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000424463	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000463687	ENST00000559624	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000463687	ENST00000382727	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000463687	ENST00000263791	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000463687	ENST00000560648	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+
intron-intron	ENST00000463687	ENST00000559311	VPS8	chr3	184588593	+	EIF2AK4	chr15	40318178	+

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FusionProtFeatures for VPS8_EIF2AK4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
VPS8 Q8N3P4	EIF2AK4 Q9P2K8

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Fusion gene ID: 41647

FusionGeneSummary for VPS8_EIF2AK4

FusionProtFeatures for VPS8_EIF2AK4