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Fusion gene ID: 41616 |
FusionGeneSummary for VPS4A_VPS4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS4A_VPS4A | Fusion gene ID: 41616 | Hgene | Tgene | Gene symbol | VPS4A | VPS4A | Gene ID | 27183 | 27183 |
| Gene name | vacuolar protein sorting 4 homolog A | vacuolar protein sorting 4 homolog A | |
| Synonyms | SKD1|SKD1A|SKD2|VPS4|VPS4-1 | SKD1|SKD1A|SKD2|VPS4|VPS4-1 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 4ASKD1-homologhVPS4vacuolar protein sorting factor 4Avacuolar sorting protein 4 | vacuolar protein sorting-associated protein 4ASKD1-homologhVPS4vacuolar protein sorting factor 4Avacuolar sorting protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UN37 | Q9UN37 | |
| Ensembl transtripts involved in fusion gene | ENST00000254950, ENST00000564399, | ENST00000254950, ENST00000564399, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 2 X 4=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VPS4A [Title/Abstract] AND VPS4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VPS4A | GO:0016192 | vesicle-mediated transport | 11563910 |
| Hgene | VPS4A | GO:0032880 | regulation of protein localization | 18005716 |
| Hgene | VPS4A | GO:0051301 | cell division | 17853893 |
| Tgene | VPS4A | GO:0016192 | vesicle-mediated transport | 11563910 |
| Tgene | VPS4A | GO:0032880 | regulation of protein localization | 18005716 |
| Tgene | VPS4A | GO:0051301 | cell division | 17853893 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ334182 | VPS4A | chr16 | 69353383 | - | VPS4A | chr16 | 69353425 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000254950 | ENST00000254950 | VPS4A | chr16 | 69353383 | - | VPS4A | chr16 | 69353425 | + |
| 5CDS-intron | ENST00000254950 | ENST00000564399 | VPS4A | chr16 | 69353383 | - | VPS4A | chr16 | 69353425 | + |
| intron-3CDS | ENST00000564399 | ENST00000254950 | VPS4A | chr16 | 69353383 | - | VPS4A | chr16 | 69353425 | + |
| intron-intron | ENST00000564399 | ENST00000564399 | VPS4A | chr16 | 69353383 | - | VPS4A | chr16 | 69353425 | + |
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FusionProtFeatures for VPS4A_VPS4A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS4A | VPS4A |