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Fusion gene ID: 41611 |
FusionGeneSummary for VPS41_SDK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS41_SDK1 | Fusion gene ID: 41611 | Hgene | Tgene | Gene symbol | VPS41 | SDK1 | Gene ID | 27072 | 221935 |
| Gene name | VPS41, HOPS complex subunit | sidekick cell adhesion molecule 1 | |
| Synonyms | HVPS41|HVSP41|hVps41p | - | |
| Cytomap | 7p14.1 | 7p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 41 homologS53vacuolar assembly protein 41vacuolar protein sorting 41 homolog | protein sidekick-1sidekick homolog 1, cell adhesion molecule | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P49754 | Q7Z5N4 | |
| Ensembl transtripts involved in fusion gene | ENST00000310301, ENST00000395969, ENST00000466017, | ENST00000404826, ENST00000389531, ENST00000466611, | |
| Fusion gene scores | * DoF score | 9 X 7 X 8=504 | 7 X 7 X 8=392 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/504*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VPS41 [Title/Abstract] AND SDK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DU-6399-01A | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000310301 | ENST00000404826 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| In-frame | ENST00000310301 | ENST00000389531 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| 5CDS-intron | ENST00000310301 | ENST00000466611 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| In-frame | ENST00000395969 | ENST00000404826 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| In-frame | ENST00000395969 | ENST00000389531 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| 5CDS-intron | ENST00000395969 | ENST00000466611 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| 5UTR-3CDS | ENST00000466017 | ENST00000404826 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| 5UTR-3CDS | ENST00000466017 | ENST00000389531 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
| 5UTR-intron | ENST00000466017 | ENST00000466611 | VPS41 | chr7 | 38835065 | - | SDK1 | chr7 | 4150295 | + |
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FusionProtFeatures for VPS41_SDK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS41 | SDK1 |