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Fusion gene ID: 41587 |
FusionGeneSummary for VPS37A_VCAM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS37A_VCAM1 | Fusion gene ID: 41587 | Hgene | Tgene | Gene symbol | VPS37A | VCAM1 | Gene ID | 137492 | 7412 |
| Gene name | VPS37A, ESCRT-I subunit | vascular cell adhesion molecule 1 | |
| Synonyms | HCRP1|PQBP2|SPG53 | CD106|INCAM-100 | |
| Cytomap | 8p22 | 1p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 37AESCRT-I complex subunit VPS37Ahepatocellular carcinoma-related protein 1polyglutamine binding protein 2vacuolar protein sorting 37 homolog A | vascular cell adhesion protein 1CD106 antigen | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q8NEZ2 | P19320 | |
| Ensembl transtripts involved in fusion gene | ENST00000324849, ENST00000324815, ENST00000521829, ENST00000521005, ENST00000521162, | ENST00000370119, ENST00000347652, ENST00000294728, ENST00000370115, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 1=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: VPS37A [Title/Abstract] AND VCAM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | VCAM1 | GO:0007155 | cell adhesion | 16809613 |
| Tgene | VCAM1 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 1715889 |
| Tgene | VCAM1 | GO:0007159 | leukocyte cell-cell adhesion | 1381355|1715889|2688898 |
| Tgene | VCAM1 | GO:0007160 | cell-matrix adhesion | 18308860 |
| Tgene | VCAM1 | GO:0009308 | amine metabolic process | 23474851 |
| Tgene | VCAM1 | GO:0042102 | positive regulation of T cell proliferation | 1381355 |
| Tgene | VCAM1 | GO:0050901 | leukocyte tethering or rolling | 18308860 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI276643 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000324849 | ENST00000370119 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| 3UTR-3UTR | ENST00000324849 | ENST00000347652 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| 3UTR-3UTR | ENST00000324849 | ENST00000294728 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| 3UTR-3UTR | ENST00000324849 | ENST00000370115 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-intron | ENST00000324815 | ENST00000370119 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000324815 | ENST00000347652 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000324815 | ENST00000294728 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000324815 | ENST00000370115 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-intron | ENST00000521829 | ENST00000370119 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521829 | ENST00000347652 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521829 | ENST00000294728 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521829 | ENST00000370115 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-intron | ENST00000521005 | ENST00000370119 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521005 | ENST00000347652 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521005 | ENST00000294728 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521005 | ENST00000370115 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-intron | ENST00000521162 | ENST00000370119 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521162 | ENST00000347652 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521162 | ENST00000294728 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
| intron-3UTR | ENST00000521162 | ENST00000370115 | VPS37A | chr8 | 17152987 | - | VCAM1 | chr1 | 101204216 | - |
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FusionProtFeatures for VPS37A_VCAM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS37A | VCAM1 |