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Fusion gene ID: 41559 |
FusionGeneSummary for VPS18_VPS18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS18_VPS18 | Fusion gene ID: 41559 | Hgene | Tgene | Gene symbol | VPS18 | VPS18 | Gene ID | 57617 | 57617 |
| Gene name | VPS18, CORVET/HOPS core subunit | VPS18, CORVET/HOPS core subunit | |
| Synonyms | PEP3 | PEP3 | |
| Cytomap | 15q15.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 18 homologhVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18 | vacuolar protein sorting-associated protein 18 homologhVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9P253 | Q9P253 | |
| Ensembl transtripts involved in fusion gene | ENST00000220509, ENST00000558474, | ENST00000220509, ENST00000558474, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: VPS18 [Title/Abstract] AND VPS18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VPS18 | GO:0007032 | endosome organization | 18799622 |
| Hgene | VPS18 | GO:0007040 | lysosome organization | 18799622 |
| Tgene | VPS18 | GO:0007032 | endosome organization | 18799622 |
| Tgene | VPS18 | GO:0007040 | lysosome organization | 18799622 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU155386 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000220509 | ENST00000220509 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
| 5CDS-intron | ENST00000220509 | ENST00000558474 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
| intron-3CDS | ENST00000558474 | ENST00000220509 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
| intron-intron | ENST00000558474 | ENST00000558474 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
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FusionProtFeatures for VPS18_VPS18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS18 | VPS18 |